Sickle haemoglobin, haemoglobin C and malaria mortality feedbacks

Sickle-cell anaemia, sickle-cell thalassaemia, sickle-cell haemoglobin C disease, and asymptomatic haemoglobin C thalassaemia in one Ghanaian family.

A Ghanaian family is described in which a sickle-cell haemoglobin C man married to a sickle-cell thalassaemia woman produced 12 children (eight alive). Four children have sickle-cell anaemia, two sickle-cell haemoglobin C disease, one has sickle-cell thalassaemia, and one is asymptomatic haemoglobin C thalassaemia.It is emphasized that the contribution that adult sickle-cell disease patients ma...

Sickle-cell haemoglobin C disease in London.

The manifestations of the sickling disorders are becoming increasingly familiar to clinicians in Great Britain. One of these disorders, sickle-cell haemoglobin disease, has hitherto received little attention, being regarded as a relatively mild condition. This paper describes some of the distinctive clinical features of the disease as seen in a series of nine cases which have recently presented...

The haemoglobin pattern of sickle cell and haemoglobin C beta +-thalassaemia in Liberia.

Haemoglobin components in 21 Liberians with Hb S beta +-thalassaemia and four with Hb C beta +-thalassaemia were measured to classify the forms of beta +-thalassaemia present in the population. In 20 Hb S and all Hb C beta +-thalassaemics the data were consistent with the interaction of these variants with the mild type 2 (Negro) form of beta +-thalassaemia. The data available were insufficient...

Properties of sickle-cell haemoglobin.

Pulmonary endarterectomy in sickle cell haemoglobin C disease.

Based on an early diagnosis and reversal of the underlying predisposing condition, this patient with subacute presentation of mediastinal zygomycosis was treated successfully with AMB and L-AMB. Along with histoplasmosis and tuberculosis, zygomycosis should be considered in patients with clinical manifestations of chronic mediastinitis and bronchial perforations. H-C. Liu*, M-S. Jan, Y-C. Lin, ...